華南農業大學生命科學學院導師：蔣珺 正文

[導師姓名]
蔣珺

[所屬院校]
華南農業大學

[基本信息]
導師姓名：蔣珺
性別：
人氣指數：1123
所屬院校：華南農業大學
所屬院系：生命科學學院
職稱：副研究員
導師類型：碩導
招生專業：細胞生物學、生物化學與分子生物學、生物工程

[通訊方式]
辦公電話：020-38604967
電子郵件：jiangjun@scau.edu.cn
通訊地址：廣州天河區五山路483號華南農業大學

[個人簡述]
蔣珺，女，博士，華南農業大學生命科學學院副研究員，碩士生導師。2009年畢業于中國科學院水生生物研究所，獲遺傳學博士學位。2009年-2011年，在華南農業大學生化與分子生物學系從事博士后工作，期間分別獲得博士后科學基金面上資助和特別資助，并以高級研究助理身份赴香港李嘉誠醫學院解剖學系進修。在博士后研究期間，首次揭示豬CYP3A46能催化T-2毒素發生3’-羥化反應。目前，主要從事豬、雞細胞色素P450氧化酶（特別是參與T-2毒素代謝的細胞色素P450氧化酶）的功能、結構及表達調控機制研究。在蛋白表達純化、酶動力學分析、啟動子活性檢測等方面有著豐富的研究經驗。累積發表SCI論文21篇，其中第一作者論文7篇，累積影響因子超80。

[科研工作]
科研項目
1.國家自然科學基金青年科學基金項目，No.31201716，2013.1-2015.12，21萬，主持，在研
2.高等學校博士學科點專項科研基金新教師類，No.20124404120012，2013.1-2015.12，4萬，主持，在研
3.廣東省自然科學基金博士啟動項目，No.S2012040007667，2012.10-2014.10，3萬，主持，在研
4.中國博士后科學基金特別資助第4批，No.201104362，2011.4-2012.9，10萬，主持，結題
5.中國博士后科學基金面上資助第47批，No.20100470930，2010.4-2011.9，3萬，主持，結題
6.國家重點基礎研究發展計劃（973計劃）子課題，No.2009CB118802，2009.1-2013.8，412萬，參加（學術骨干），結題
發表論文
1.ShirleyM.H.Sy§,JunJiang§,WaiSumO,YiqunDeng,MichaelS.Y.Huen.2013.TheUbiquitinSpecificProteaseUSP34PromotesUbiquitinSignalingatDNADouble-StrandBreaks.NucleicAcidsResearch.41(18):8572-8580.(5-YrIF:8.055)(§co-firstauthor)
2.HuaCai§,JunJiang§,QiYang,QingmeiChen,YiqunDeng.2012.FunctionalCharacterizationofaFirstAvianCytochromeP450oftheCYP2DSubfamily(CYP2D49).PLoSOne.7(6):e38395.(5-YrIF:4.244)(§co-firstauthor)
3.JiansheWang§,JunJiang§,HongxiaZhang,JunpingWang,HuaCai,ChengLi,KangbaiLi,JingLiu,XuejiangGuo,GuangxunZou,DazhiWang,YiqunDeng,JiayinDai.2011.IntegratedtranscriptionalandproteomicanalysiswithinvitrobiochemicalassayrevealtheimportantroleofCYP3A46inT-2toxinhydroxylationinporcineprimaryhepatocytes.MolecularandCellularProteomics.10(9):10.1074/mcp.M111.008748,1-18.(5-YrIF:8.051)(§co-firstauthor)
4.ShirleyM.-H.Sy§,JunJiang§,Sui-suiDong,GabrielTsz-MeiLok,JunWu,HuaCai,EnochS.L.Yeung,JunHuang,JunjieChen,YiqunDeng,MichaelS.Y.Huen.2011.CriticalrolesofringfingerproteinRNF8inreplicationstressresponses.JournalofBiologicalChemistry.286(25):22355-22361.(5-YrIF:5.023)(§co-firstauthor)
5.JunJiang,JunpingWang,HuaCai,KangbaiLi,YiqunDeng.2011.CYP3Ascatalyzenifedipineoxidationinpiglivermicrosomes:enzymekinetics,inhibitionandfunctionalexpression.CatalysisCommunications.12(8):694-697.(5-YrIF:3.328)
6.JunJiang,Yi-BingZhang,ShunLi,Fei-FeiYu,FanSun,Jian-FangGui.2009.ExpressionregulationandfunctionalcharacterizationofanovelinterferoninduciblegeneGig2anditspromoter.MolecularImmunology.46(15):3131-3140.(5-YrIF:2.917)
7.Jian-HongXia§,JunJiang§,Yao-HuaShi,Jian-FangGui.2009.PredominantexpressionandcellulardistributionoffishAgr2inrenalcollectingsystem.ComparativeBiochemistryandPhysiologyPartB:BiochemistryandMolecularBiology.152(4):397-404.(5-YrIF:2.092)(§co-firstauthor)
8.FanSun,Yi-BingZhang,JunJiang,BingWang,ChenChen,JunZhang,Jian-FangGui.2014.Gig1,anovelantiviraleffectorinvolvedinfishinterferonresponse.Virology.448:322-332.(5-YrIF:3.164)
9.PeiqiangMu,MingXu,LeiZhang,KaixinWu,JunWu,JunJiang,QingmeiChen,LijuanWang,XianqingTang,YiqunDeng.2013.ProteomicchangesinchickenprimaryhepatocytesexposedtoT-2toxinareassociatedwithoxidativestressandmitochondrialenhancement.Proteomics.13(21):3175-3188.(5-YrIF:4.223)
10.ShufengShang,JunJiang,YiqunDeng.2013.ChickenCytochromeP4501A5istheKeyEnzymeforMetabolizingT-2Toxinto3'OH-T-2.InternationalJournalofMolecularSciences.14(6):10809-10818.(5-YrIF:2.732)
11.Yi-BingZhang,Ting-KaiLiu,JunJiang,JunShi,YingLiu,ShunLi,Jian-FangGui.2013.IdentificationofanovelGig2genefamilyspecifictonon-amniotevertebrates.PLoSOne.8(4):e60588.(5-YrIF:4.244)
12.JieChen,WanjuanFeng,JunJiang,YiqunDeng,MichaelS.Y.Huen.2012.RingFingerProteinRNF169AntagonisestheUbiquitin-DependentSignalingCascadeatSitesofDNADamage.JournalofBiologicalChemistry.287(33):27715-27722.(5-YrIF:5.023)
13.XianqingTang,PeiqiangMu,JunWu,JunJiang,CaihuiZhang,MingZheng,andYiqunDeng.2012.CarbonylReductionofMequindoxbyChickenandPorcineCytosolandClonedCBR1.DrugMetabolismandDisposition.40(4):788-795.(5-YrIF:3.678)
14.JingLiu,ManOuyang,JunJiang,PeiqiangMu,JunWu,QiYang,CaihuiZhang,WeiyingXu,LijuanWang,MichaelS.Y.Huen,YiqunDeng.2012.MequindoxinducedcellularDNAdamageviagenerationofreactiveoxygenspecies.MutationResearch-GeneticToxicologyandEnvironmentalMutagenesis.741(1-2):70-75.(5-YrIF:2.843)
15.MingZheng,JunJiang,JunpingWang,XianqingTang,ManOuyang,YiqunDeng.2011.TheMechanismofEnzymaticandNon-enzymaticN-oxideReductiveMetabolismofCyadoxinPigLiver.Xenobiotica.41(11):964–971.(5-YrIF:2.302)
16.JingLiu,XiaohuGe,ManOuyang,XianqingTang,JunWu,JunpingWang,JunJiang,MichaelS.Y.Huen,YiqunDeng.2011.CatalyticcharacteristicsofCYP3A22-dependentmequindoxdetoxification.CatalysisCommunications.12(7):637-643.(5-YrIF:3.382)
17.XiaohuGe,JunpingWang,JingLiu,JunJiang,HuinaLin,JunWu,ManOuyang,XianqingTang,MingZheng,MingLiao,YiqunDeng.2010.ThecatalyticactivityofcytochromeP4503A22iscriticalforthemetabolismofT-2toxininporcinereservoirs.CatalysisCommunications.12(2):71-75.(5-YrIF:3.382)
18.Fei-FeiYu,Yi-BingZhang,Ting-KaiLiu,YingLiu,FanSun,JunJiang,Jian-FangGui.2010.Fishvirus-inducedinterferonexertsantiviralfunctionthroughStat1pathway.MolecularImmunology.47(14):2330-2341.(5-YrIF:2.917)
19.YanShi,Yi-BingZhang,ZheZhao,JunJiang,Qi-YaZhang,Jian-FangGui.2008.MolecularcharacterizationandsubcellularlocalizationofCarassiusauratusinterferonregulatoryfactor-1.Developmental&ComparativeImmunology.32(2):134-146.(5-YrIF:3.4)
20.Yi-BingZhang,JunJiang,Yu-DongChen,RongZhu,YanShi,Qi-YaZhang,Jian-FangGui.2007.Theinnateimmuneresponsetograsscarphemorrhagicvirus(GCHV)inculturedCarassiusauratusblastulae(CAB)cells.Developmental&ComparativeImmunology.31(3):232-243.(5-YrIF:3.4)
21.Yu-DongChen,Yi-BingZhang,RongZhu,Fu-TieZhang,JunJiang,YanShi,Qi-YaZhang,Song-LinChen,Jian-FangGui.2005.InductiveexpressionandcharacterizationanalysisofParalichthysolivaceuspigmentepithelium-derivedfactorinavirallyinfectedcellline.BiochemicalandBiophysicalResearchCommunications.335(3):799-809.(5-YrIF:2.5)

[教育背景]

華南農業大學

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