姚陳娟 ，博士

學歷和職歷：

南通醫學院衛生系 學士學位

江蘇省通州市衛生防疫站 醫師

南通醫學院衛生系勞動衛生學教研室 助教

日本德島大學 訪問學者

2002.4-2006.3 日本德島大學 博士學位

2006.4-2008.3 日本德島大學 助教

2009.4- 南通大學公共衛生學院 教授

2010.4-2011.3 美國加州大學舊金山分校 博士后

研究方向：有害物質毒性的分子機制

科研項目：

1．砷的生物轉運及其調控機制研究，國家自然科學基金項目（20877045）主持人

2．鋅離子抑制細胞和組織吸收三價無機砷機制研究 國家自然科學基金項目（21277078）第二參加者

近三年發表的論文：

1．Anderson MO, Zhang J, Liu Y, Yao C, Phuan PW, Verkman AS．Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B．J Med Chem．2012 Jun 28;55(12):5942-50．Epub 2012 Jun 19．PubMed PMID．22694147.

2．Yao C, Anderson MO, Zhang J, Yang B, Phuan PW, Verkman AS．Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration．J Am Soc Nephrol．2012 Jul;23(7):1210-20．Epub 2012 Apr 5．PubMed PMID．22491419; PubMed Central PMCID．PMC3380644.

3．Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ．Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice．Bioconjug Chem．2011 Dec 21;22(12):2593-9． Epub 2011 Nov 18．PubMed PMID．22034937; PubMed Central PMCID: PMC3245868.

4．Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS．Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease．J Med Chem．2011 Aug 11;54(15):5468-77．Epub 2011 Jul 12．PubMed PMID．21707078; PubMed Central PMCID．PMC3314378.

5：Purwanti N, Tsuji D, Azlina A, Karabasil MR, Javkhlan P, Hasegawa T, Yao C, Akamatsu T, Itoh K, Hosoi K．Induction of Sca-1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct．J Oral Pathol Med．2011 Sep;40(8):651-8．doi．10.1111/j.1600-0714.2011.01011.x．Epub 2011 Feb 25． PubMed PMID．21884259.

6．Purwanti N, Karabasil MR, Matsuo S, Chen G, Javkhlan P, Azlina A, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct．Am J Physiol Gastrointest Liver Physiol．2011 Nov;301(5):G814-24．Epub 2011 Aug 25．PubMed PMID．21868636.

7．Hosoi K, Yao C．[Suppression of aquaporin 5 gene expression by endotoxin via cross-coupling of transcription factors]．Seikagaku．2011 Jul;83(7):632-8．Review．Japanese．PubMed PMID． 21866876.

8．Hasegawa T, Azlina A, Javkhlan P, Yao C, Akamatsu T, Hosoi K．Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling in salivary gland cells．Am J Physiol Cell Physiol．2011 Sep;301(3):C667-78．Epub 2011 Jun 1．PubMed PMID．21633078.

9．Karabasil MR, Hasegawa T, Azlina A, Purwanti N, Yao C, Akamatsu T, Tomioka S, Hosoi K．Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats．Biol Cell．2011 Feb;103(2):69-86．PubMed PMID．21138418.

10．Javkhlan P, Hiroshima Y, Azlina A, Hasegawa T, Yao C, Akamatsu T, Kido J, Nagata T, Hosoi K． Lipopolysaccharide-mediated induction of calprotectin in the submandibular and parotid glands of mice．Inflammation．2011 Dec;34(6):668-80．PubMed PMID． 21125321.

11．Azlina A, Javkhlan P, Hiroshima Y, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation．Am J Physiol Gastrointest Liver Physiol．2010 Nov;299(5):G1106-17．Epub 2010 Aug 5．PubMed PMID．20689061.

12．Yao C, Purwanti N, Karabasil MR, Azlina A, Javkhlan P, Hasegawa T, Akamatsu T, Hosoi T, Ozawa K, Hosoi K．Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos．Am J Pathol．2010 Aug;177(2):724-34．Epub 2010 Jun 3．PubMed PMID．20522648; PubMed Central PMCID: PMC2913374.

13．Karabasil MR, Hasegawa T, Azlina A, Purwanti N, Purevjav J, Yao C, Akamatsu T, Hosoi K．Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif ((152)SRRTS) in MDCK-II cells．J Med Invest．2009 Feb;56(1-2):55-63．PubMed PMID．19262015.

14．Karabasil MR, Murdiastuti K, Purwanti N, Azlina A, Javkhlan P, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking．J Med Invest．2009;56 Suppl:398-400．PubMed PMID．20224238.

15．Wang C, Chen G, Jiang J, Qiu L, Hosoi K, Yao C．Aquaglyceroporins are involved in uptake of arsenite into murine gastrointestinal tissues．J Med Invest．2009;56 Suppl:343-6．PubMed PMID． 20224220.

16．Javkhlan P, Hiroshima Y, Azlina A, Hasegawa T, Yao C, Akamatsu T, Kido J, Nagata T, Hosoi K．Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice．J Med Invest．2009;56 Suppl:287-9．PubMed PMID．20224205.

17．Azlina A, Li X, Javkhlan P, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Down-regulation of submandibular gland AQP5 following parasympathetic denervation in rats．J Med Invest．2009;56 Suppl:273-6． PubMed PMID．20224200.

18．Purwanti N, Azlina A, Karabasil MR, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular gland of mice．J Med Invest．2009;56 Suppl:253-4．PubMed PMID． 20224192.

19．Akamatsu T, Azlina A, Javkhlan P, Hasegawa T, Yao C, Hosoi K．Salivary gland development．its mediation by a subtilisin-like proprotein convertase, PACE4．J Med Invest．2009;56 Suppl:241-6．Review．PubMed PMID．20224189.

20.Aquaglyceroporins are involved in uptake of arsenite into murine gastrointestinal tissues．J Med Invest．2009;56 Suppl:343-6.通訊作者

21．細菌脂多糖經p38絲裂原激活蛋白激酶通路調節claudin-11基因的表達 毒理學雜志, 2009(2):104-107．通訊作者

22．細菌脂多糖誘導單核細胞趨化蛋白-1在小鼠睪丸中表達 中國免疫學雜志,2009(12):1105-1107．第三

23．三價無機砷在大小小鼠組織中蓄積差異研究 中華預防醫學雜志,2009,43(10):932-933．通訊作者

24．雙酚A在染毒雄性大鼠血清中時間-濃度關系 中華預防醫學雜志,2010,44(1):30-33．通訊作者

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