四川大學生命科學學院導師：曾凡亞 正文

　　
　　姓名：曾凡亞　性別：男
　　職稱：教授　學院：生命科學院
　
　　聯系方式：02885418926，15884558137；
　　Email：zengfanya@scu.edu.cn
　　
　　學位簡歷和工作簡歷
　　1979.09 – 1983.07 四川大學，生物系，本科（獲理學學士學位）
　　1983.07 – 1989.09 四川大學，生物系，助教
　　1989.10 – 1992.02 法國南巴黎大學，訪問學者
　　1992.02 – 1994.08 四川大學，生物系，講師
　　1994.09 – 1998.07 四川大學，生命科學學院，博士（獲理學博士學位）
　　1998.07 – 2003.10 四川大學，生命科學學院，副教授
　　2003.10 – 2006.11 香港大學，動物學系，博士后
　　2006.11 – 2008.04 香港大學，生命科學學院，高級研究助理
　　2008.04 – 2012.02 四川大學，生命科學學院，教授
　　
　　研究方向
　　分子病毒學 — 沙士冠狀病毒、豬繁殖與呼吸綜合征病毒的基因組、遺傳進化、疫苗免疫、和分子流行病學
　　
　　主持的研究項目
　　糙皮側耳線粒體基因組全序列測定及基因組分析（國家自然科學基金2000-2002）
　　
　　發表文章
　　Yip CW, Hon CC, Shi M, Lam TT, Chow KY, Zeng F, Leung FC. Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses. Infect Genet Evol. 2009, 9(6):1185-96.
　　Lam TT, Hon CC, Pybus OG, Kosakovsky Pond SL, Wong RT, Yip CW, Zeng F, Leung FC. Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia. PLoS Pathog. 2008, 4(8):e1000130
　　Wang Y, Zeng F, Hon CC, Zhang Y, Leung FC. The mitochondrial genome of the Basidiomycete fungus Pleurotus ostreatus (oyster mushroom). FEMS Microbiol Lett. 2008, 280(1):34-41.
　　Hon CC, Lam TY, Shi ZL, Drummond AJ, Yip CW, Zeng F, Lam PY, Leung FC. Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus. J Virol. 2008, 82(4):1819-26.
　　Yeung YS, Yip CW, Hon CC, Chow KY, Ma IC, Zeng F, Leung FC. Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation. Virology. 2008, 371(1):32-43.
　　Lam TY, Hon CC, Wang Z, Hui RK, Zeng F, Leung FC. Evolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events. Virus Res. 2008, 131(2):271-8.
　　Wong RT, Hon CC, Zeng F, Leung FC. Screening of differentially expressed transcripts in infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA microarrays. J Gen Virol. 2007, 88:1785-96.
　　Yip CW, Hon CC, Zeng F, Chow KY, Chan KH, Peiris JS, Leung FC. Naturally occurring anti-Escherichia coli protein antibodies in the sera of healthy humans cause analytical interference in a recombinant nucleocapsid protein-based enzyme-linked immunosorbent assay for serodiagnosis of severe acute respiratory syndrome. Clin Vaccine Immunol. 2007, 14(1):99-101.
　　Zeng F, Hon CC, Yip CW, Law KM, Yeung YS, Chan KH, Malik Peiris JS, Leung FC. Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein in virus neutralization and blocking of receptor binding: implications for the functional roles of S2 subunit. FEBS Lett. 2006, 580(24):5612-20.
　　Yip CW, Yeung YS, Ma CM, Lam PY, Hon CC, Zeng F, Leung FC. Demonstration of receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Vero cells. Virus Res. 2007, 123(1):50-6.
　　Chow KY, Yeung YS, Hon CC, Zeng F, Law KM, Leung FC. Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells. FEBS Lett. 2005, 579(30):6699-704.
　　Hon CC, Lam TY, Drummond A, Rambaut A, Lee YF, Yip CW, Zeng F, Lam PY, Ng PT, Leung FC. Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B. J Virol. 2006, 80(17):8503-9.
　　Zeng F, Hon CC, Sit WH, Chow KY, Hui RK, Law IK, Ng VW, Yang XT, Leung FC, Wan JM. Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray. Int J Oncol. 2005, 27(2):513-23.
　　Hui RK, Zeng F, Chan CM, Yuen KY, Peiris JS, Leung FC. Reverse transcriptase PCR diagnostic assay for the coronavirus associated with severe acute respiratory syndrome. J Clin Microbiol. 2004, 42(5):1994-9.
　　Zeng F, Chow KY, Hon CC, Law KM, Yip CW, Chan KH, Peiris JS, Leung FC. Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments. Biochem Biophys Res Commun. 2004, 315(4):1134-9.
　　Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC. Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet. 2004, 363(9403):99-104.
　　Zeng F, Chow KY, Leung FC. Estimated timing of the last common ancestor of the SARS coronavirus. N Engl J Med. 2003, 349(25):2469-70.
　　Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang CY, Wang PY, Guan Y, Zheng B, Poon LL, Chan KH, Yuen KY, Peiris JS, Leung FC. The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39). Exp Biol Med (Maywood). 2003, 228(7):866-73.
　　 

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