天津科技大學生物工程學院導師：謝希賢

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天津科技大學生物工程學院導師：謝希賢正文

[導師姓名]
謝希賢

[所屬院校]
天津科技大學

[基本信息]
導師姓名：謝希賢
性別：男
人氣指數：488
所屬院校：天津科技大學
所屬院系：生物工程學院
職稱：教授
導師類型：
招生專業：微生物與生化藥學

[通訊方式]
辦公電話：022-60601251
電子郵件：xixianxie@tust.edu.cn
通訊地址：天津經濟技術開發區第十三大街29號，天津科技大學生物工程學院

[個人簡述]
發明申請專利：[1]谷氨酸棒桿菌及采用該菌發酵生產α-酮戊二酸的方法，ZL201110392778.8。[2]解淀粉芽孢桿菌添加前體物發酵法生產抗病毒藥物利巴韋林的生產工藝，ZL201310097836.3。[3]利用重組表達核糖磷酸酶生產5-肌苷酸的方法，ZL201410032597.8。[4]Hydroxy-and dicarboxylic-fat synthesis by microbes US 2015/0225753 A1.[5]一種L-異亮氨酸羥化酶基因及其基因工程菌與應用，ZL201410132444.0。[6]一株產α-酮基丁酸的基因工程菌及其應用，201410132996.1。[7]一種產生四氫嘧啶的基因工程菌及其構建方法與應用，201510410080.2。[8]一種耐酸性蘇氨酸生產菌及其構建方法與應用，201510579005.9。[9]一種α-酮基丁酸發酵生產工藝，201510579553.1。[10]一種羥基四氫嘧啶的制備方法，201510638769.0獲獎情況：[1]芳香族氨基酸及衍生物關鍵技術研究與產業化，中國輕工業聯合會，科技進步獎，一等獎，2015。[2]谷氨酸清潔生產和廢水綜合利用關鍵技術研究與應用，中國輕工業聯合會，科技進步獎，二等獎，2015。[3]分支鏈氨基酸代謝調控技術及產業化，天津市，科技進步獎，二等獎，2013。[4]谷氨酸棒桿菌蘇氨酸脫氨酶基因敲除及對L-亮氨酸發酵的影響，中國食品科學技術學會，科技創新獎，一等獎，2011。[5]梅花味精教師獎，二等獎，2009。

[科研工作]
[1]Ning Y Wu X Zhang C Xu Q Chen N* Xie X*. Pathway construction and metabolic engineering for fermentativeproduction of ectoine inEscherichia coli. Metabolic Engineering 2016 36:10-18.IF: 6.767[2]ZhangC Qi J Li Y Fan X Xu Q Chen N Xie X*. Production of α-ketobutyrate using engineered Escherichia coli via temperature shift. Biotechnology and Bioengineering 2016 doi: 10.1002/bit.25959. IF: 4.126[3]Gui Y Ma Y Xu Q Zhang C Xie X* Chen N. Complete genome sequence of Corynebacterium glutamicum CP a Chinese l-leucine producing strain. Journal of Biotechnology 2016 220:64-65. IF: 2.871[4]Li Y Sun L Feng J Wu R Xu Q Zhang C Chen N Xie X*. Efficient production of α-ketoglutarate in the gdh deleted Corynebacterium glutamicum by novel double-phase pH and biotin control strategy. Bioprocess and Biosystems Engineering 2016 doi:10.1007/s00449-016-1576-y. IF: 1.997[5]Zhang C Du S Liu Y Xie X Xu Q Chen N*. Strategy for enhancing adenosine production under the guidance of transcriptional and metabolite pool analysis. Biotechnol Lett. 2015 37(7):1361-1369. IF: 1.591[6]Wang J Wen B Xu Q Xie X Chen N*. Optimization of carbon source and glucose feeding strategy for improvement of L-isoleucine production by Escherichia coli. Biotechnol Biotechnol Equip. 2015 29(2):374-380.[7]Xie X Liang Y Liu H Liu Y Xu Q Zhang C Chen N.*Modification of glycolysis and its effect on the production of L-threonine in Escherichia coli. J Ind Microbiol Biotechnol 2014 41:1007-1015. IF: 2.439[8]Ma Y Yang S Liu L Xu Q Zhang C Chen N Xie X*. Fermentative production of ribavirin by overexpressing purine nucleoside phosphorylase in Bacillus.J Chem Pharm Res 2014 6(5):1377-1384. EI[9]Xu L Xie X Shi J Xu Q Chen N*.Expression of the Escherichia coli tdcB gene encoding threoninedehydratase in L-isoleucineoverproducingCorynebacterium Glutamicum Yilw. Appl Biochem Microbiol 2013 49(2) 125-129. IF: 0.658[10]Wang J Wen B Wang Jian Xu Q Zhang C Chen N XieX*. Enhancing l-isoleucine production bythrABCoverexpression combined withalaTdeletion inCorynebacterium glutamicum. Appl Biochem Biotech 2013 171(1):20-30.IF: 1.893[11]Cheng Y Zhou Y Yang L Zhang C Xu Q Xie X Chen N*. Modification of histidine biosynthesis pathway genes and the impact on production of L-histidine in Corynebacterium glutamicum. Biotechnol Lett. 2013 5(5):735-741. IF: 1.736[12]Guo X Wang J Xie X Xu Q Zhang C Chen N*. Enhancing the supply of oxaloacetate for L-glutamate production by pyc overexpression in different Corynebacterium glutamicum.Biotechnol Lett. 2013 35(6):943-950. IF: 1.736[13]Fang H Liu H Chen N* Zhang C Xie X Xu Q. Site-directed mutagenesis studies on the uridine monophosphate binding sites of feedback inhibition in carbamoyl phosphate synthetase and effects on cytidine production by Bacillus amyloliquefaciens. Can J Microbiol. 2013 59(6):374-9. IF: 1.182[14]Liang J Zhang D Guo X Xu Q Xie X Zhang C Bai G Xiao X Chen N*. At-line near-infrared spectroscopy for monitoring concentrations in temperature-triggered glutamate fermentation. Bioprocess Biosyst Eng. 2013 36(12):1879-1887. IF: 1.823[15]Fang H Xie X Xu Q Zhang C Chen N*. Enhancement of cytidine production by coexpression of gnd zwf and prs genes in recombinant Escherichia coli CYT15. Biotechnol Lett. 2013 35(2):245-251. IF: 1.736[16]Liu Q Cheng Y Xie X Xu Q Chen N*. Modification of tryptophan transport system and its impact on production of L-tryptophan in Escherichia coli. Bioresour Technol.2012 114:549-554.IF: 4.75[17]Xie X Huo W Xia J Xu Q Chen N*. Structure-activity relationship of a cold-adapted purine nucleoside phosphorylase by site-directed mutagenesis. Enzyme Microb Technol.2012 51(1):59-65.IF: 2.592[18]Xie X Xu L Shi J Xu Q Chen N*. Effect of transport proteins on L-isoleucine production with the L-isoleucine-producing strain Corynebacterium glutamicumYILW. J Ind Microbiol Biotechnol. 2012 39(10): 1549-1556. IF: 2.321[19]Shen T Liu Q Xie X Xu Q Chen N*. Improved production of tryptophan in genetically engineered Escherichia coli with TktA and PpsA overexpression. J Biomed Biotechnol. 2012 2012:605219. IF: 2.88[20]Xie X Xia J Xu Q He K Lu L Chen N*. Low-molecular-mass homotrimer purine nucleotide phosphorylase: characterization and application in enzymatic synthesis of nucleoside antiviral drugs. Biotechnol Lett. 2011 33(6):1107-1112. IF: 1.683[21]Xie X Wang G Xia J Chen N. Characterization of a recombinant cold-adapted purine nucleoside phosphorylase and its application in ribavirin bioconversion. World J Microbiol Biotechnol. 2011 27:1175-1181. IF: 1.532[22]Chen N* Xing C Xie X Xu Q. Optimization of technical conditions of producing ribavirin by Bacillussubtilis. Ann Microbiol 2009 59(3):525-530.[23]Xie X Xu L Yang F*. 2006. Proteomic analysis of the major envelope and nucleocapsid proteins of white spot syndrome virus (WSSV). J. Virol. 80:10615-10623.[24]Xie X Yang F*. 2006. White spot syndrome virus VP24 interacts with VP28 and is involved in virus infection. J. Gen. Virol. 87:1903-1908.[25]Xie X Yang F*. 2005. Interaction of white spot syndrome virus VP26 protein with actin. Virology 336:93-99.[26]Xie X Li H Xu L Yang F*. 2005. A simple and efficient method for purification of intact white spot syndrome virus (WSSV) viral particles. Virus Res. 108:63-67.

[教育背景]
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